Clinical Genomics Variant Analysis Director

Company: LabCorp
Location: Campbell
Posted on: March 1, 2026

Job Description:

Labcorp is seeking a US remote-based Variant Analysis Director to join its team. Responsibilities: Provide strategic, technical, and operational leadership for clinical interpretation and reporting activities across core technologies including whole genome sequencing (WGS), whole exome sequencing (WES), targeted NGS panels, and chromosomal microarray (CMA) Serve as a subject matter expert in genomic testing workflows, interpretation frameworks, and clinical reporting standards, ensuring scientific rigor, clinical relevance, and regulatory compliance Oversee day-to-day operational performance, including production scheduling, capacity planning, process health monitoring, and escalation of operational incidents Establish, optimize, and scale end-to-end workflows for clinical interpretation and reporting, applying continuous improvement methodologies to improve efficiency, quality, and throughput Define, implement, and monitor key operational metrics to assess performance, identify risk, and communicate status, trends, and opportunities to senior leadership Ensure delivery of high-quality clinical reports that meet established turnaround time, accuracy, and quality benchmarks Lead diagnosis and resolution of complex production issues, driving root-cause analysis and implementation of sustainable corrective and preventive actions Develop and execute operational strategies and goals aligned with broader organizational objectives and key results Act as an individual-contributor Director with significant strategic and operational scope, with the expectation of evolving people leadership responsibilities as the organization scales Mentor and coach scientists, genetic counselors, and operational partners, fostering a culture of continuous learning, accountability, and scientific excellence Collaborate cross-functionally with Laboratory, Bioinformatics, Product, Quality, Regulatory, IT, and Clinical Development teams to support successful launch of new assays, tools, and initiatives Provide input into strategic planning, organizational design, and capacity modeling through data-driven insights Foster a culture of operational excellence, best practices, and professional growth Perform other duties as assigned in support of departmental and company goals Minimum Qualifications: PhD in Biological Sciences, Molecular Genetics, Human Genetics, or a related field, with 5 years of related work experience OR Master’s degree in Genetic Counseling, Biological Sciences, Molecular Genetics, Human Genetics, or a related field, with 6 years of related work experience OR Bachelor’s degree in Genetics, Biological Sciences, Molecular Genetics, Human Genetics, or a related field with 7 years of related work experience 5 years of experience in operational leadership, including managing a team, workflow optimization, capacity planning, performance metrics, and cross-functional execution Additional Job Standards: Clinical genomics or molecular diagnostics experience in a CLIA-certified or similarly regulated laboratory environment Variant interpretation, curation, and clinical reporting for NGS-based assays, including WGS, WES, and/or targeted panels Operational leadership supporting clinical interpretation or reporting workflows, including capacity planning, quality management, and process optimization Cross-functional collaboration with laboratory, bioinformatics, product, quality, regulatory, or clinical development teams Experience supporting the development, launch, or scaling of clinical genomic assays or interpretation programs Demonstrated ability to independently lead complex initiatives and influence outcomes without direct people management responsibility Strong understanding of clinical reporting operations, quality systems, and regulated laboratory environments (e.g., CLIA, CAP) Proven ability to operate at a Director level, balancing strategic planning with hands-on operational leadership Strong analytical, problem-solving, and communication skills, with the ability to translate technical and operational data into executive-level insights Demonstrated technical expertise with whole genome sequencing (WGS) and whole exome sequencing (WES), including strong understanding of clinical interpretation frameworks, reporting standards, and end-to-end workflows Excellent written, verbal, and interpersonal communication skills Ability to follow standard operating procedures with accuracy and attention to detail Ability to adapt to significant change that is inherent in development and innovation Desire to work in and contribute to a fast-paced, highly collaborative environment Demonstrated ability to understand, synthesize, and coherently evaluate complex genetic information. Lean Six Sigma certification (Green Belt or higher) or demonstrated experience applying Lean, Six Sigma, or similar continuous improvement methodologies in a scaled operational environment preferred Director-level experience within a CLIA-certified diagnostic laboratory or similarly regulated clinical setting preferred Deep familiarity with next-generation sequencing technologies and clinical interpretation frameworks, including variant curation and assessment of clinical relevance preferred Knowledge of advanced copy number detection methodologies and copy number variant (CNV) interpretation across CMA and NGS-based platforms preferred Experience with rapid or NICU whole genome sequencing (NICU WGS), including high-acuity clinical workflows, expedited turnaround requirements, and cross-functional coordination preferred Experience or strong interest in one or more clinical domains, including oncology, cardiology, neurology, carrier screening, metabolic disorders, pediatric diagnostics, cytogenomics, and/or exome analysis preferred Demonstrated experience scaling clinical interpretation or reporting operations in a high-throughput, regulated environment preferred Knowledge of advanced copy number detection methodologies and copy number variant (CNV) interpretation across CMA and NGS-based platforms preferred This is a Director-level position with leadership accountability, though it does not presently include direct people-management responsibilities. Over time, the role is expected to transition into a formal people-lead position. Application Window Closes: 3/6/2026 Salary Range: $125,000 - $200,000/ year All job offers will be based on a candidate’s skills and prior relevant experience, applicable degrees/certifications, as well as internal equity and market data. The position is also eligible for an annual bonus under the Labcorp Bonus Plan. Bonuses are payable based on corporate and/or business segment performance and are subject to individual performance modifiers. Benefits: Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(k), Paid Time Off (PTO) or Flexible Time Off (FTO), Tuition Reimbursement and Employee Stock Purchase Plan. Casual, PRN & Part Time employees regularly scheduled to work less than 20 hours are eligible to participate in the 401(k) Plan only. Employees who are regularly scheduled to work a 7 on/7 off schedule are eligible to receive all the foregoing benefits except PTO or FTO. For more detailed information, please click here. Labcorp is proud to be an Equal Opportunity Employer: Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. Additionally, all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law. We encourage all to apply If you are an individual with a disability who needs assistance using our online tools to search and apply for jobs, or needs an accommodation, please visit our accessibility site or contact us at Labcorp Accessibility. For more information about how we collect and store your personal data, please see our Privacy Statement.

Keywords: LabCorp, San Francisco , Clinical Genomics Variant Analysis Director, Science, Research & Development , Campbell, California