Scientist I, Medicinal Chemistry
Company: Maze Therapeutics
Location: South San Francisco
Posted on: January 1, 2026
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Job Description:
The Position We’re looking for a passionate scientist with
experience in synthetic organic chemistry to join our collaborative
drug discovery team. In this lab-based role, you’ll design and
synthesize novel molecules that could transform patient care.
You’ll work closely with colleagues across disciplines to optimize
compounds for potency, selectivity, and pharmacokinetics, and
contribute to advancing innovative drug discovery programs. The
Impact You’ll Have Design and synthesize novel chemical entities
aligned with project goals. Conduct multistep syntheses of complex
small molecules and characterize intermediates and final products.
Collaborate with chemists, biologists, and external partners to
optimize pharmacological properties. Contribute to patents,
reports, and scientific publications. Present project results and
strategy in key company meetings. Mentor junior colleagues and
troubleshoot synthetic challenges using literature and best
practices. What We’re Looking For Ph.D. in synthetic organic
chemistry or related discipline, or M.S. with 5 years industry
experience, or B.S. with 10 years industry experience. Proven
expertise in chemical synthesis (publications or industry
achievements). Strong collaboration skills and a proactive,
solution-oriented approach. Familiarity with medicinal chemistry
concepts and ability to learn quickly. Enthusiasm for applying
chemistry to solve complex challenges at the intersection of
genetics, functional genomics, and biology. Excellent communication
skills and attention to detail. About Maze Therapeutics Maze
Therapeutics is a clinical-stage biopharmaceutical company
harnessing the power of human genetics to develop novel, small
molecule precision medicines for patients living with renal,
cardiovascular and related metabolic diseases, including obesity.
The company is advancing a pipeline using its Compass platform,
which allows it to identify and characterize genetic variants in
disease and then link those variants to the biological pathways
that drive disease in specific patient groups through a process it
refers to as variant functionalization. The company’s pipeline is
led by two wholly owned lead programs, MZE829 and MZE782, each of
which represents a novel precision medicine-based approach for
chronic kidney disease. Maze is based in South San Francisco. Our
People Maze is comprised of a team of passionate and creative
professionals committed to discovering and delivering
transformative medicines to patients suffering from both rare and
common genetic diseases. We are fostering a culture that encourages
vision, initiative and the development of talent. Our supportive
work environment inspires creative thinking and freedom of
expression, resulting in a stimulating atmosphere where people
enjoy coming to work. While we have a passion for advanced science
and pride ourselves on excellence in execution, ultimately,
everything we do is about patients. Our Core Values Further
Together – Our path is paved with challenges, but with resilience
and a team-first mentality, we’ll achieve our mission. Impact
Obsessed – We embrace the bold, take calculated risks, and learn
from our mistakes to improve the lives of others. Stand True – Our
integrity is foundational; it guides us no matter the obstacle. The
expected annual salary range for employees located in the San
Francisco Bay Area is $134,000 - $163,000. Additionally, this
position is eligible for an annual performance bonus. Maze performs
position-based compensation benchmarking to industry market data to
ensure we pay competitive wages. Determination of starting salary
will depend upon a variety of job-related factors, which may
include professional experience, skills, and job location. The
expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees
including competitive medical, dental, and vision insurance, mental
health offerings, equity incentive plan, 401(k) program with
employer match and a generous holiday and PTO policy. LI-Hybrid
Keywords: Maze Therapeutics, San Francisco , Scientist I, Medicinal Chemistry, Science, Research & Development , South San Francisco, California
