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Senior Scientist - Centers Innovation Therapeutics

Company: Pfizer Inc.
Location: San Francisco
Posted on: October 13, 2019

Job Description:

ROLE SUMMARY
Pfizer's Centers for Therapeutic Innovation (CTI) is a pioneering research unit that partners with leading academic medical centers and disease foundations to translate novel breakthroughs into therapies that change patients' lives. CTI laboratories in Manhattan and San Francisco are assembling a cross-disciplinary team to explore the underlying tenets of disease biology in the integrated space of DNA damage response pathways, chromatin biology, cancer drug tolerance, heterogeneity and immunology/inflammation. This is a unique opportunity for driven, exceptional scientists to leverage their expertise and develop their scientific acumen & drug discovery skills while collaborating with multidisciplinary research teams at Pfizer and academic subject-matter experts.

Successful candidates will work collaboratively with biology teams, portfolio project teams and other post-docs to further our understanding of chromatin biology, DNA damage response, cancer drug tolerance, heterogeneity, innate immunity and other areas of emerging science. While performing independent, cutting-edge research, scientists will join forces with experienced drug hunters, colleagues focusing on target identification and validation, hit discovery, as well as pre-clinical animal studies and safety, with the goal of making clinically-relevant, groundbreaking discoveries and publishing in high-impact journals.

ROLE RESPONSIBILITIES

  • Demonstrate deep scientific and technical expertise harnessed to advance our understanding in the fields of heterogeneous drug responses, chromatin biology and/ or innate immunity, produce high-impact publications, present at conferences and ultimately contribute to the delivery of novel, life-changing therapies for patients.
  • Independently design and test biological hypotheses, while also leveraging the breadth of expertise available from colleagues and subject matter experts across Pfizer and the external academic collaborative network.
  • Execute targeted in vitro and in vivo experiments, while leveraging state of the art technologies and resources to address fundamental questions regarding cancer drug resistance mechanisms that can uncover novel therapeutic angles in this space.
  • Generate, organize, analyze, interpret data, and identify areas where key knowledge is lacking. Provide organizational support for junior members of the team Proactively seek new scientific leads via genetics & AI-based resources, literature, conferences and key opinion leaders with the goal of refining scientific hypothesis and expediting experimental plans.
  • Effectively communicate results at internal and external events and proactively contribute to the continued scientific growth at Pfizer.
  • Contribute to a culture that embraces scientific excellence, effectiveness, and team-work.
    QUALIFICATIONS
    • Ph.D. in molecular and cell biology, cancer biology, epigenetics and chromatin biology, immuno-oncology, immunology, or a related field is preferred, 2+ years Postdoctoral experience OR
    • MS with 7+ years biotechnology/pharma experience, or BS with 10+ years of biotechnology/pharma experience
    • Significant expertise with an array of molecular and cell biological techniques, including genome editing methods, protein and chromatin biochemistry, chromatin immunoprecipitations and other assays that assess chromatin states, multi-color flow cytometry, mass spectrometry analysis, bioinformatics analysis and/ or in vivo models for oncology and other therapeutic areas.
    • Must have excellent organizational and planning skills, and the motivation and ability to work in a fast-paced environment independently and as part of a team.
    • Excellent verbal and written communication skills. Ability to quickly master new concepts and techniques.
      PREFERRED QUALIFICATIONS
      • Direct experience with cancer cell heterogeneity, transposable element biology/analysis, nucleic acid sensing mechanisms, innate immunity and /or chromatin biology
        Other Information:
        - Eligible for Employee Referral Bonus
        - Eligible for Relocation Benefit

        #LI-PFE

        Sunshine Act
        Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

        EEO & Employment Eligibility
        Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
        N (Other) (United States of America)
        Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Keywords: Pfizer Inc., San Francisco , Senior Scientist - Centers Innovation Therapeutics, Other , San Francisco, California

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