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Scientist II, Biology (BS/MS Level Only)

Company: Pharmacyclics, LLC
Location: Sunnyvale
Posted on: June 17, 2019

Job Description:

Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

To learn more about us, please visit us at

General Position Summary/Purpose:
The Scientist II will be a key member of the Research Biology team responsible for providing strong technical expertise and implementation to support drug discovery and novel target identification and validation in hematologic malignancies. The candidate will be responsible for executing tasks to achieve departmental and project goals. The candidate should be proficient in standard molecular biology, cell culture and biochemistry techniques and is expected to clearly communicate the scientific rationale, methodology and results in written and oral formats.

Key Accountabilities/Core Job Responsibilities:

  • Demonstrate scientific knowledge and independence to establish and implement strategies for exploring the mechanisms of action of novel molecules to support translation into future therapies for new indications in hematological malignancies.
  • Hands-on execution : Advance science from the bench, design and execute various biochemical and cellular assays to determine potency and selectivity of small molecules to understand their SAR and mechanism of action
  • Work with supervisors to improve assay protocols and take the leading role in the development, optimization, and validation of new assays. Utilize technical expertise and available information to troubleshoot and resolve key assay hurdles when encountered
  • Apply basic cell and molecular biology techniques to identify and evaluate cellular efficacy and selectivity endpoints
  • Perform tasks with diligent attention to detail and high level of accuracy. Prioritize tasks and contribute to a highly motivated and productive research team with a sense of urgency and desire to meet project timelines
  • Accurately document, critically analyze/interpret data and communicate the results promptly
  • Strong interpersonal skills to thrive in a team environment Qualifications:
    • BS with 7 or more years of relevant laboratory experience or MS with 5 or more years of relevant laboratory experience required with training in cancer biology. Experience working on hematologic cancers is highly desired.
    • Demonstrated ability to design, execute and interpret experiments via publications, external presentations or patents
    • Effective written and verbal English communication skills Experience:
      • Experience in cell culture (suspension and adherent) and latest molecular and cellular biology assays including but not limited to DNA/RNA/protein purification, lentiviral transduction, CRISPR, RNAi, immunoprecipitation, WES, ELISA, MSD, qPCR, and colorimetric assays
        • Expertise in multi-color immunophenotyping, flow cytometry and cell imaging techniques
        • Experience with cell-based assay development, optimization and troubleshooting
        • Experience in establishing and fully validating compound potency assays using cell lines or primary human cells is essential. Experience in using cell biology models to elucidate molecular mechanisms of action
        • Basic knowledge on biological data analysis tools (GraphPad Prism, FACS DIVA software, FlowJo, Image Studio, Compass) and computer applications such as MS Word, MS Excel and MS PowerPoint
        • Contribute to lab and equipment maintenance and help create a safe, effective and efficient working environment Equal Opportunity Employer Minorities/Women/Veterans/Disabled

          Associated topics: bio, biological engineer, biomedical, biosynthetic, hereditary, msat, neuro, pain, parenteral, pathogenesis

Keywords: Pharmacyclics, LLC, San Francisco , Scientist II, Biology (BS/MS Level Only), Other , Sunnyvale, California

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