Life Science Research Professional 3 - Research Scientist in Genetics
Company: Stanford University
Posted on: November 19, 2023
The Laboratories of Casey Gifford (Depts of Genetics and
Pediatrics) and Jesse Engreit (Dept of Genetics) are seeking a
Research Scientist (Life Science Research Professional 3) focusing
on human and mouse genetics, genome editing, and genomics to lead a
project to understand the genetic basis of congenital heart
defects. The Gifford and Engreitz Laboratories are located in the
Biomedical Innovations Building on the main campus at Stanford
University and are members of the BASE Initiative in the Betty
Irene Moore Children's Heart Center, a collaboration with Drs. Mark
Skylar-Scott (Dept of Bioengineering) and Marlene Rabinovitch (Dept
Project overview: DNA regulatory elements in the human genome,
which harbor thousands of genetic risk variants for common and rare
heart diseases and could reveal targets for therapeutics that aim
to precisely tune cellular functions - if only we could map the
complex regulatory wiring that connects 2 million regulatory
elements with 21,000 genes in thousands of cell types in the human
body. We have recently developed new approaches that could enable
mapping this regulatory wiring at massive scale (see Fulco et al.
Science 2016, Fulco et al. Nat Genet 2019, Nasser et al. Nature
2021), and applied these and other approaches to understand the
genetic basis of congenital heart defects (Gifford et al. Science
2019, Schricker et al. Nature 2019, Ameen et al. bioRxiv 2022). We
have now identified enhancers that contain disease variants that
affect risk for congenital heart defects, and aim to study the
functions of these enhancers in mouse models and human cardiac
organoids. These studies will ultimately help to uncover biological
mechanisms of congenital heart defects, and help to guide diagnosis
and treatment for children with heart disease. For information and
recent work, see https://www.caseygiffordlab.com,
We are looking for creative and passionate people at any stage in
their career (see other job postings). The Gifford and Engreitz
Laboratories are located adjacent to one another and provide a
dynamic, interdisciplinary workplace with unique access to cutting
edge technologies and scientific thought, with the potential for
widespread recognition of scientific contributions. We value a
diversity of values, backgrounds, and approaches to solving
The candidate for this position should have hands-on experience in
mouse genetics, molecular biology, genomics, and cellular assay
development; experience with quantitative data analysis; curiosity
in research and creativity in problem-solving; strong interpersonal
and collaboration skills; experience building or managing teams;
outstanding verbal and written communication abilities; ability to
adapt to and effectively manage changes in a fast paced and dynamic
environment; and have a passion for science and sense of urgency to
find new medicines to benefit patients.
In addition to submitting your application via the Stanford web
portal, please email your CV and cover letter directly to Profs.
Casey Gifford (firstname.lastname@example.org) and Jesse Engreitz
Make fundamental discoveries about gene regulation and the genetics
of cardiovascular disease.
Together with PI and other lab members, design and execute
Develop and apply strategies to study enhancers and genes in human
cells and mouse models.
Evaluate and recommend new emerging technologies, approaches, and
Train and collaborate with other lab members in experimental
techniques, scientific design, and other skills.
Design and lead independent projects.
Collaborate with a team of experimentalists and computational
Create scientifically rigorous visualizations, communications, and
presentations of results.
Contribute to generation of protocols, publications, and
* - Other duties may also be assigned.
Ph.D. in Biology, Biochemistry, Biophysics, Genetics,
Bioengineering, Developmental Biology, or related life science
field is preferred. Highly motivated candidates of all levels are
encouraged to apply.
Expert in mouse genetics, with experience studying embryoic or
heart development a plus.
Experience in technology development, molecular biology, genomics,
and cellular assay development.
Experience with quantitative data analysis.
Experience with CRISPR targeting ES/iPS cells or single-cell
RNA-seq a plus.
Curiosity in research and creativity in problem-solving.
A great team member with strong interpersonal and collaboration
Outstanding verbal and written communication abilities.
Ability to adapt to and effectively manage changes in a fast paced
and dynamic environment.
A passion for science and sense of urgency to find new medicines to
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field and four years of
relevant work experience; or Master's degree in a related
scientific field and two years relevant experience; or PhD in
related science field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles.
Expert level knowledge and skills in field of science related to
General computer skills and experience with databases and
Strong analytical skills and excellent judgment.
Ability to work under deadlines with general guidance is
Excellent organizational skills and demonstrated ability to
complete detailed work accurately.
Developing project management skills.
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly,
use fine manipulation, grasp forcefully, perform desk-based
computer tasks, use telephone, write by hand, lift, carry, push and
pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders,
sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level,
and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Position may require repetitive motion.
* - Consistent with its obligations under the law, the University
will provide reasonable accommodation to any employee with a
disability who requires accommodation to perform the essential
functions of his or her job.
May require working in close proximity to blood borne
May require work in an environment where animals are used for
teaching and research.
Position may at times require the employee to work with or be in
areas where hazardous materials and/or infectious diseases are
Employee must perform tasks that require the use of personal
protective equipment, such as safety glasses and shoes, protective
clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research
requirements and business needs.
Interpersonal Skills: Demonstrates the ability to work well with
Stanford colleagues and clients and with external
Promote Culture of Safety: Demonstrates commitment to personal
responsibility and value for safety; communicates safety concerns;
uses and promotes safe behaviors based on training and lessons
Subject to and expected to comply with all applicable University
policies and procedures, including but not limited to the personnel
policies and other policies found in the University's
Administrative Guide, http://adminguide.stanford.edu.
The expected pay range for this position is $82,000 to $102,000 per
annum. Stanford University provides pay ranges representing its
good faith estimate of what the university reasonably expects to
pay for a position. The pay offered to a selected candidate will be
determined based on factors such as (but not limited to) the scope
and responsibilities of the position, the qualifications of the
selected candidate, departmental budget availability, internal
equity, geographic location and external market pay for comparable
As an organization that receives federal funding, Stanford
University has a COVID-19 vaccination requirement that will apply
to all university employees, including those working remotely in
the United States and applicable subcontractors. To learn more
about COVID policies and guidelines for Stanford University Staff,
Keywords: Stanford University, San Francisco , Life Science Research Professional 3 - Research Scientist in Genetics, Other , Stanford, California
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