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Senior Scientist/Principal Scientist, Target Biology

Company: Scorpiontx
Location: San Francisco
Posted on: March 20, 2023

Job Description:

Sr. Scientist/Principal, Target Biology
We are seeking a highly motivated cancer biologist to join our Target Biology team in South San Francisco. The successful candidate will play a key role in target validation and early drug discovery efforts by utilizing cutting edge functional genomic techniques and developing/implementing a variety of biochemical and cell-based methods to elucidate target function and enable small molecule screening efforts. They will deeply explore the target biology to refine indication space and/or biomarker hypotheses, mechanistically "connect the dots" from target engagement to phenotype in disease-relevant contexts, and study potential mechanisms of resistance. As a core member of the biology group, they will collaborate closely with other functional groups to drive project momentum and communicate key biology updates cross-functionally.

  • Evaluate novel precision oncology targets through genetic and pharmacological approaches.
  • Leverage and expand on current CRISPR-based screening approaches to enable early stage pipeline advancement.
  • Design and execute a series of experiments to drive in depth target validation, elucidate mechanistic biology to inform targeting modality, and identify biomarkers to generate hypotheses for early patient stratification.
  • Design, develop, and implement robust biochemical- and cell-based assays to characterize drug/target MoA and measure compound potency and selectivity.
  • Collect, analyze, and summarize data for presentations, reports, publications, and patents.
  • Keep up to date with the latest scientific advances in technologies and trends in oncology research and development, and contribute to group strategy.
  • Mentor and direct junior lab members.
  • Maintain excellent communication across internal and external team members.


    • Ph.D. with a focus on cancer biology, cell or molecular biology, genetics or a closely related area of study and 5+ years of additional experience in oncology discovery (can include postdoc); BS/MS with 12+ years industry experience.
    • Broad technical experience sufficient to design and execute target validation and MoA studies (CRISPR, RNAi, genetic rescue, general molecular biology, etc.).
    • Experience designing, executing, and analyzing genome-wide CRISPR screens.
    • Experience developing scalable and robust cell-based assays to enable drug discovery.
    • Demonstrated ability to independently and consistently lead projects from concept/hypothesis through major milestones (pipeline advancement or impactful publication).
    • Exceptional scientific rigor and commitment to the highest-quality research with outstanding organizational abilities and scientific execution.
    • A highly engaged, self-starter who is creative, innovative, communicative and possesses both a collaborative and goal/results-orientated style.
    • Desire to work in a fast-paced, multi-tasking environment, while employing tact, patience, diplomacy and a collaborative spirit.
    • Outstanding decision making, organizational and analytical skills.
    • Excellent interpersonal and communication skills.

Keywords: Scorpiontx, San Francisco , Senior Scientist/Principal Scientist, Target Biology, Other , San Francisco, California

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