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Sr. Associate Scientist, Downstream Development for Protein Development & Manufacturing

Company: Vaxcyte Inc.
Location: San Carlos
Posted on: March 20, 2023

Job Description:

Company Profile:Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte's lead candidate, VAX-24, is a 24-valent, broad-spectrum pneumococcal conjugate vaccine being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company's system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte's pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of greater than 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit .Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 100 employees and anticipates continued, significant growth. On January 6, 2022, Vaxcyte announced that the U.S. Food and Drug Administration (FDA) had cleared the Investigational New Drug (IND) application for VAX-24, its lead vaccine candidate. The Company initiated the VAX-24 Phase 1/2 clinical proof-of-concept study in adults in the first quarter of 2022 and expects to announce Phase 2 topline immunogenicity, safety, and tolerability results by the end of the year. VAX-24 was designed to prevent IPD, which can be most serious for infants, young children, older adults and those with immune deficiencies or certain chronic health conditions. Given the global impact of pneumococcal disease remains significant, the public health community continues to advocate for vaccines that can offer broader protection to prevent IPD. Vaxcyte's PCV franchise, consisting of VAX-24 and VAX-XP, is designed specifically to address this need and has the potential to deliver the broadest protection for this very serious disease.Summary:Vaxcyte is looking for an energetic and talented individual to join our protein process development and manufacturing group. As a member of this group, you'll have the opportunity to work with cutting edge technologies to design purification processes for life-saving vaccines. The successful candidate will have the following skills and qualities: -An exceptional team member that fosters a highly collaborative work environment. -A confident individual who speaks up, is open to input, and remains focused on achieving the best results to achieve company goals. -A diligent scientist/engineer who enjoys process execution and scale up. -The ability to clearly present data, trend longitudinal data, draw conclusions, and communicate salient points concisely. -A strong sense of ownership and accountability; commitment to Vaxcyte's mission.Essential Functions:

  • Execution of chromatography, tangential flow filtration, and normal flow filtration systems.
  • Create process records that clearly instruct and efficiently facilitate capture of data.
  • Plan and manage logistics of routine pilot production of proteins to support Vaxcyte's pipeline.
  • Support scale up activities for processes as part of technology transfer to CMOs.
  • Contribute to process development for protein processes.
  • Run in-process tests and product quality assays to support pilot production.
  • Participate in technology transfer activities for the process developed at Vaxcyte to an external CMO for GMP production.Requirements:
    • BS in Chemical Engineering, Biochemistry, or a related discipline, with 5+yearsofindustryexperience.
    • Strong protein purification knowledge and experience, including familiarity with AKTA chromatography systems and UNICORN software.
    • Proficiency running analytical methods a plus; such methods may include SDS-PAGE, Endosafe, UV spectroscopy, and HPLC.
    • Experience operating tangential flow filtration systems; single-pass TFF is a plus.
    • Experience with Benchling ELN is a plus.
    • Strong interpersonal skills, with excellent written and verbal communication skills.
    • All Vaxcyte employees require vaccination against COVID-19.Reports to: Associate Director, Downstream Development for Protein Development & ManufacturingLocation: San Carlos, CACompensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.Salary Range: $71,000 - $84,000Send resumes to: Vaxcyte, Inc. 825 Industrial Road, Suite 300San Carlos, CA 94070

Keywords: Vaxcyte Inc., San Francisco , Sr. Associate Scientist, Downstream Development for Protein Development & Manufacturing, Other , San Carlos, California

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