Senior Scientist I - Non-Viral Delivery
Company: Mammoth Biosciences
Location: Brisbane
Posted on: January 27, 2023
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Job Description:
Mammoth BioSciencesOPPORTUNITYMammoth Biosciences is hiring for
a Senior Scientist I, Non-viral Delivery. In this role the ideal
candidate will be responsible for leading the lipid nanoparticle
(LNP) formulation discovery and scale up activities for non-viral
delivery technologies at Mammoth. The candidate will be responsible
for the screening of various lipids and formulation/process
parameters for the lead optimization for delivery of Mammoth's
proprietary CRISPR nucleases. In addition, they will be responsible
for in-house research-scale production, related process
development, and quality control of the test articles to support
Mammoth's ex vivo and in vivo studies. KEY RESPONSIBILITIES Lead
DOE-based LNP formulation screening/discovery campaigns directed
toward in vivo and ex vivo delivery of Mammoth's proprietary
CRISPR-based gene editing systems Design, implement and execute
early process development activities for LNP scale-upCritically
review and analyze data, and communicate results and conclusions;
present and defend ideas in cross-functional meetingsExplore and
evaluate non-viral delivery technologies for various therapeutics
indicationsExplore new orthogonal characterization assays and
rigorously QC all the test articlesManage the non-viral delivery
projects to support deliverables along established timelinesTrain,
guide, and manage the researchers on various non-viral delivery
activitiesREQUIRED QUALIFICATIONSBachelor's degree in related field
and 8+ years industry experience (or Master's degree and 6+ years
experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical
engineering, Biomedical Engineering, Statistics or related
discipline with 2+ years of industry experience)Expertise in LNP
formulation screening and optimization Expertise in using design of
experiment (DOE), relevant statistical softwares (JMP), and
predictive analytics for formulation discoveryPREFERRED
QUALIFICATIONS Exposure to LNP scale-up and process development
activitiesHands-on expertise in various basic analytical and
biophysical methods/assays of LNP characterization such as,
particularly size, zeta potential, and nucleic acid
encapsulation/release, PKa, etc. Foundation in experimental
documentation, basic statistical analysis and data presentation
Experience working with internal and external research
collaborators and CROsHighly motivated, hard working, and
collaborative spiritBENEFITSCompany-paid health/vision/dental
benefitsUnlimited vacation and generous sick timeCompany-sponsored
meals and snacksWellness, caregiver, and ergonomics benefits401(k)
with company matchingCOMPANYMammoth Biosciences is harnessing the
diversity of life to power the next generation of CRISPR products.
Through the discovery and engineering of novel CRISPR systems, the
company is enabling the full potential of its platform to read and
write the code of life. Mammoth aims to develop permanent genetic
cures through best-in-class in vivo and ex vivo therapies and to
democratize disease detection with on-demand diagnostics. Mammoth
can provide enhanced diagnostics and genome editing for life
science research, healthcare, agriculture, biodefense and more.
Based in the San Francisco Bay Area, Mammoth Biosciences is
co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and
Trevor Martin, Janice Chen, and Lucas Harrington. The firm is
backed by top institutional investors including Redmile Group,
Foresite Capital, Senator Investment Group, Sixth Street, Decheng,
Mayfield, NFX, and 8VC, along with leading individual investors
including Brook Byers, Tim Cook, and Jeff Huber.TEAMOur small-size
proteins, such as Cas14 and CasPhi, are poised to transform disease
treatment enabling novel editing approaches and delivery options
that are difficult to achieve or not even possible with previously
described CRISPR-Cas systems. Our teams are responsible for
discovering and engineering novel CRISPR systems, and translating
our unique CRISPR technology into therapeutic treatments with the
ultimate goal of cures for indications with high medical need.It is
our policy and intent to provide equal opportunity to all persons
without regard to race, color, religion, political affiliation,
sex/gender (including gender expression/identity, pregnancy,
childbirth, and related medical conditions), marital status,
registered domestic partner status, sexual orientation, age,
ancestry, national origin, veteran status, disability, medical
condition, genetic characteristics, and/or any other basis
protected by law. This policy covers all facets of employment
including, but not limited to: recruitment, selection, placement,
promotions, transfers, demotions, terminations, training, and
compensation.Mammoth Biosciences requires that all employees be
vaccinated against Covid-19 as a condition of at-will employment,
with exceptions for medical or religious reasons in compliance with
local, state, and federal law. PI202148609
Keywords: Mammoth Biosciences, San Francisco , Senior Scientist I - Non-Viral Delivery, Other , Brisbane, California
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