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Associate Scientist, Process Development (Contractor)

Company: Allogene Therapeutics
Location: San Francisco
Posted on: November 26, 2022

Job Description:

About Allogene Therapeutics, Inc:Allogene Therapeutics is a clinical-stage biotechnology company with a single-minded focus on pioneering the development of investigational allogeneic chimeric antigen receptor T cell (AlloCAR T---) products for cancer. Led by world-class management with significant experience in cell therapy, our fully integrated, in-house team of researchers is dedicated to discovery and translational research, development, and cell manufacturing.At Allogene, we are developing a pipeline of off-the-shelf CAR T cell candidates, with the goal of delivering readily available cell therapy faster, more reliably, and at greater scale to more patients. For more information, please visit , and follow @AllogeneTx on Twitter and LinkedIn.About the role:Allogene is seeking a temporary Associate Scientist to support the development and characterization of clinical-scale manufacturing processes for Allogene's CAR T therapies.This individual will contribute to the development, implementation, and characterization of state-of-the-art processing technologies to deliver scalable and robust manufacturing processes and support successful tech transfer for GMP manufacturing and release at a CMO. This position will also contribute to the development of novel technologies and approaches to meet future CAR T manufacturing needs.Responsibilities include, but are not limited to:

  • Actively contribute to development, implementation, characterization, and successful execution of robust, state-of-the-art CART manufacturing processes.
  • Support clinical-scale non-GMP/ GMP IND-enabling manufacturing operations, including Tech Transfer to CMO and support of successful GMP manufacturing of clinical material.
  • Contribute to relevant and impactful innovation programs to enhance CAR T manufacturing technologies/ capabilities and work-processes (such as alternate transfection/ cell engineering strategies, media development, disposable/ closed production systems and automation), aligned with emerging business drivers and regulatory expectations.
  • Contribute to Project Technical Teams and communicate and collaborate effectively to ensure effective interactions with all stakeholder groups.
  • Ensure high-quality, timely documentation in electronic laboratory notebooks and Technical Reports and contribute to Regulatory Filings and responses to Regulatory questions as appropriate.
  • Present data/strategy to scientists (and management) in internal venues (technical meetings, Project Team meetings) as appropriate.
  • Remain current with the process engineering and chemistry literature. May collaborate and author external publications and present research at external conferences.
    Position Requirements & Experience:

    • MS or BS in Chemical Engineering, Biochemistry, Molecular & Cell Biology, Immunology
    • Experience with prior Gene & Cell Therapy manufacturing preferred, but not required.
    • A demonstrated foundational understanding of mammalian or primary cell culture, biochemistry, molecular & cell biology, and immunology (required for enhanced product & process understanding).
    • Experience in flow cytometry for T cells characterization preferred, but not required.
    • Experience in FMEA, process characterization and DOE methodologies in biologics or cell therapy space preferred.
    • Experience in genetic modification of cells using gene edit and gene delivery technologies preferred, but not required.
    • Experience with continuous manufacturing processes including operation in upstream genetic modification and bioreactor/WAVE expansion, and cryopreservation preferred.
    • Ability to work in a fast-paced, startup environment.
    • Strong attention to detail with the ability to multi-task and handle multiple responsibilities simultaneously.
    • Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines.
    • Ability to work independently and as part of a team.
    • Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment.
    • Candidates must be authorized to work in the U.S.
      As an equal opportunity employer, Allogene is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment and internships designed to create a stronger and better Allogene that is focused on developing life-changing products for patients.Please be aware that the FBI recently issued a warning about an increased number of fake job postings for remote work employment that target applicants' personally identifiable information. All approved Allogene Therapeutics positions are accessible via the Allogene Careers page at .

Keywords: Allogene Therapeutics, San Francisco , Associate Scientist, Process Development (Contractor), Other , San Francisco, California

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