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Senior Scientist/Principal Scientist, Chemistry - Small Molecule Process Chemistry

Company: Genentech
Location: San Francisco
Posted on: November 26, 2022

Job Description:

The Position Genentech is seeking a top-tier Senior/ Principal Scientist with a proven record of sustained laboratory achievement and innovation to join our Small Molecule Process Chemistry group. The Senior/ Principal Scientist, leading from the bench as part of our project-based research and development staff, will be responsible for:

  • Evaluating and executing enabling chemistry during late stage research programs in support of development-readiness decisions
  • Designing, developing and executing processes to manufacture GMP starting materials, advanced intermediates, and active pharmaceutical ingredients (APIs) in early clinical development through late-stage route selection
  • Establishing fit-for-purpose syntheses of diverse therapeutic modalities, which may include synthetic small molecules, oligonucleotides, peptides, polymer linkers, conjugation strategies, and purification techniques.
  • Using the chemistry developed, the Scientist, working with our South San Francisco clinical manufacturing team, will participate in the production of early phase GMP clinical supplies.
  • Eventual route selection for late stage GMP API manufacturing is also the responsibility of the Scientist and includes the concepts of safe, efficient, robust, environmentally sound chemistry, and extends to the synthesis of the regulatory starting materials and establishment of a robust supply chain. The successful candidate will be responsible for developing processes suitable for controlling the quality of bulk API as required by cGMP, ICH and FDA regulations as well as the bulk attributes conducive to successful formulation development. In addition, writing relevant CMC sections of INDs and participating in developing a strategy for quality are important tasks. The position's mission will be accomplished through innovation and teamwork, collaboration with strategic internal/external partners, creative problem solving and use of state-of-the-art technology. The Senior/ Principal Scientist will engage in the evaluation and deployment of techniques or instruments required for the successful preparation of small molecule and mixed-mode therapeutics, such as orally-available inhibitors, peptides, and/or antibody- or polymer-conjugates. A combination of skill sets including traditional organic synthesis, crystallization science, catalysis, solid-phase peptide synthesis (SPPS), preparative chromatography, specialized dialysis/filtration/downstream processing, and/or process analytical technology (PAT) may be required. The Senior/ Principal Scientist is expected to maintain a high-level scientific profile both internally and externally in terms of scholarly achievements and pipeline contributions. Who You Are: Successful candidates will possess the following qualifications:
    • BS/MS in relevant scientific discipline with 10+ years experience in the pharmaceutical industry in a scientific role, or PhD with 0-10 years industry experience
    • Outstanding record of innovation and success in multiple projects over the course of their academic and industrial career with a sustained publication record
    • Strong working knowledge of the latest developments in contemporary chemical synthesis (organic/process chemistry) including chemo- and bio-catalysis, organometallic chemistry as well as expertise in asymmetric transformations, heterocyclic chemistry, and/or peptide chemistry
    • Ability to interact, learn and eventually lead in a CMC/cross functional environment
    • Ability to take initiative, provide strategic input, problem solve, work in teams, develop people and communicate clearly, both orally and in writing
    • Experience manufacturing on kilogram scale and managing external projects/resources is strongly preferred The applicant should plan to submit a short Research Summary in addition to their CV. Relocation benefits are available for this position Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation. Job Facts JOB FUNCTION COMPANY/DIVISION Genentech SCHEDULE JOB TYPE Full time

Keywords: Genentech, San Francisco , Senior Scientist/Principal Scientist, Chemistry - Small Molecule Process Chemistry, Other , San Francisco, California

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