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Senior Research Associate

Company: Arsenal Biosciences
Location: San Francisco
Posted on: August 7, 2022

Job Description:

ArsenalBio's mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer. - Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments. - Our people are our greatest asset, they bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.ArsenalBio's approach to improving T cell therapies for solid tumors incorporates novel receptors and gene circuits in addition to modulation of T cell states to empower these therapies to sense their environment and respond as needed to resolve disease states with remarkable potency. We are seeking a highly talented and driven candidate to join ArsenalBio's Synthetic Biology group on the forefront of screening, development, and application of novel T cell intrinsic and extrinsic perturbations to improve therapeutic activity. You will interface closely with colleagues across ArsenalBio's Discovery, Technology, and Medical Sciences departments, as well as external collaborators and thought leaders in an exciting environment on the bleeding edge of synthetic biology and immuno-oncology.What You Will Do:

  • Engineer T cells with novel perturbations for in vitro and in vivo testing
  • Apply experience in high-throughput screening (pooled and arrayed approaches) and T cell functional assays (multicolor flow cytometry, luciferase, Incucyte, Luminex, etc.) to screen genetic and epigenetic perturbations for a portfolio of cell therapy applications
  • Coordinate tasks across multiple projects, demonstrating prioritization and planning
  • Document experimental design and generation of large scale datasets with attention to detail
  • Maintain familiarity with the relevant current literature and its application in cell therapyWhat Will You Bring:
  • For Senior Research Associate level, Bachelors or Masters in Molecular/Cell Biology, Immunology, or a related discipline with 3+ years of relevant research experience in industry or academia.
  • For Scientist level: - Ph.D. in Molecular/Cell Biology, Immunology, or a related discipline with 0-2 yrs experience OR Masters with 5+ years experience OR Bachelor with 7 + years experience.
  • Excellent organizational, written and verbal communication and interpersonal skills
  • Ability to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results with transparency and accountability
  • High level of competence with two or more of the following is required: 4+ color flow cytometry, viral or non-viral T cell editing, T cell functional assays - (T and tumor cell co-cultures, T cell cytotoxicity assays, etc.), molecular biology skills (RNA/DNA extraction, qRT-PCR, NGS, molecular cloning)
  • Experience performing data analysis required (R/Python, FlowJo, Prism, etc. is a plus) -
  • Demonstrated ability to perform as a team player in a collaborative multi-disciplinary environmentArsenalBio prioritizes the providing of a safe and healthy workplace that is consistent with COVID-19 public health guidance and legal requirements. - In order to protect our employees and visitors, we require all visitors (including candidates) and employees to present proof of being fully vaccinated against COVID-19 when coming onsite.We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity, and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

Keywords: Arsenal Biosciences, San Francisco , Senior Research Associate, Other , San Francisco, California

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