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Senior Research Associate, In Vivo Pharmacology

Company: Zai Lab (US) LLC
Location: San Francisco
Posted on: June 26, 2022

Job Description:

Primary Function
The successful candidate will be part of an in vivo pharmacology team focusing on the validation and advancement of novel cancer therapeutic candidates. -The candidate will perform hands-on experiments on rodents to examine the efficacy and mechanism of action of our anticancer therapeutics.
Major Responsibilities and Duties

  • Perform in vivo studies to test oncology and immune-oncology therapeutics.
  • Hands-on work will include cell culture, generating xenograft tumor models, intravenous (IV), intraperitoneal (IP), and intragastric -(PO) dosing of mice, as well as isolation of mouse blood (via various routes) and tissues.
  • Experiments to be performed include model development, antitumor efficacy, and PK/PD studies.
  • Support ex vivo analysis to examine drug pharmacodynamics and biomarker discovery.
  • Analyze and present data as well as rationale and design of in vivo studies to the department and project teams.
  • Work collaboratively on multiple projects concurrently and coordinate activities across functions.
    • Bachelor's or Master's degree in Biology/Oncology.
    • At least 1-5 years of hands-on in vivo experience with mice, including generating and measuring xenograft tumors, dosing via intravenous, intraperitoneal, and intragastric administration, and collection of mouse tissue and blood is required.
    • Basic cell culture experience is required.
    • Hands-on experience with various in vitro laboratory techniques will be a plus, including Western blot, qRT-PCR, ELISA, immunohistochemistry, and flow cytometry.
    • Capable of working independently in a fast-paced, team-oriented environment, demonstrating multitasking capabilities.
    • Excellent troubleshooting and data analysis skills are required.
    • Great communication skills and team spirit is a must; ability to communicate results within pharmacology team and at project team meetings required.
    • Previous industry experience is a plus.

      Additional information
      Diversity Statement: - -At Zai Lab we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.
      Zai Lab is an equal opportunity employer. Zai Lab makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.
      Recruiter Statement: -Zai Lab acknowledges that providers may be a valuable resource for identifying and recruiting candidates for employment. - However, we require that all recruiters engage directly with Zai Lab's Human Resources Team and comply with Zai Lab's requirements prior to transmitting any resumes/CVs or introducing any candidates to Zai Lab. - Zai Lab's Human Resource Team is the only function within the Company that can enter contractual relationships with external recruiters and recruiting agencies. - -

Keywords: Zai Lab (US) LLC, San Francisco , Senior Research Associate, In Vivo Pharmacology, Other , San Francisco, California

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