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Research Associate/Sr. Research Associate, Preclinical Development Sciences/DMPK

Company: Oric Pharmaceuticals, Inc.
Location: San Francisco
Posted on: June 12, 2021

Job Description:

We are seeking a highly motivated Research Associate (RA)/Senior Research Associate (SRA) in Preclinical Development Sciences to study Absorption/Distribution/Metabolism/Excretion (ADME) of drugs. S/he will be a part of ORIC drug discovery and development project teams with the goal of developing therapeutics to overcome resistance in cancer. The primary responsibilities will be to support in vivo pharmacology, pharmacokinetic and toxicology experiments with formulations and conducting in vitro ADME experiments. S/he will interpret results and troubleshoot problems in the laboratory with the guidance of other scientists in the group. S/he will have opportunities to learn and grow in drug discovery and development programs at ORIC.

Responsibilities:

  • Prepare dose formulations to support in vivo studies
  • Conduct in vitro experiments to profile ADME properties of drug candidates, such as in vitro drug metabolism, tissue/protein binding, and interpret results under the guidance of other scientists within the group
  • Operate, maintain and troubleshoot LC-MS/MS
  • Maintain accurate and detailed raw data in scientific notebooks
  • Participate in the preparation of abstracts and manuscripts for publication
  • Perform all duties in keeping with the Company's core values, policies and all applicable regulations

Qualifications & Experience:

  • Bachelor degree with 0-6 year experience (for RA); or Bachelor degree with 6-9 years (for SRA); or a Masters degree with 2-6 years industry experience (for SRA) of professional experience in a chemistry, pharmacology, or biology laboratory setting
  • Proficiency in Microsoft Office, Word, Excel, and PowerPoint
  • Excellent interpersonal skills and ability to work in a team environment
  • Enthusiasm towards learning new science
  • Hands on experience in operation, troubleshooting, maintenance of LC-MS is a plus
  • Good understanding of ADME concepts is a plus

About ORIC Pharmaceuticals:

ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients' lives by Overcoming Resistance In Cancer. ORIC's lead product candidate, ORIC-101, is a potent and selective small molecule antagonist of the glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors. ORIC-101 is currently in two separate Phase 1b trials of ORIC-101 in combination with (1) Xtandi (enzalutamide) in metastatic prostate cancer and (2) Abraxane (nab-paclitaxel) in advanced or metastatic solid tumors. ORIC's other product candidates include (1) ORIC-533, an orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy- and immunotherapy-based treatment regimens, and (2) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the embryonic ectoderm development (EED) subunit, being developed for prostate cancer, and (3) ORIC-114, a brain penetrant inhibitor designed to selectively target EGFR and HER2 with high potency against exon 20 insertion mutations, being developed across multiple genetically defined cancers. Beyond these four product candidates, ORIC is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to www.oricpharma.com.

Keywords: Oric Pharmaceuticals, Inc., San Francisco , Research Associate/Sr. Research Associate, Preclinical Development Sciences/DMPK, Other , San Francisco, California

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