Post Doctoral Scientist
Company: Sutter Health
Location: San Francisco
Posted on: June 13, 2021
KEY WORDS: Science/R&D, Cell Biology,Chemistry,
Genomics,Molecular Biology,Cancer Biology,
PharmacologyScience/R&D, Cell Biology,Chemistry,
Genomics,Molecular Biology,Cancer Biology, Pharmacology
Job Summary and other information regarding this
The California Pacific Medical Center Research Institute is a
dynamic group of scientists and clinical investigators focused on
biomedical, clinical and translational research. We are the
research component of Sutter Health's California Pacific Medical
Center, a large multi-campus medical center in San Francisco.
Currently we are seeking a self-motivated, innovative and
independent scientist to join the laboratory of Dr. Mohammed
Kashani-Sabet, whose focus is the identification of novel markers
and mediators of the cancer progression, and the development of
novel targeted therapies for cancer, with a principal focus on
melanoma. To date, our laboratory has assigned pro-metastatic
function to several genes in melanoma and other cancers, including
NCOA3, BPTF, and PHIP (see references below). Ongoing work is
attempting to further develop several of these as therapeutic
targets. The successful candidate will work in the Kashani lab and
also with other faculty in CPMCRI Precision Medicine Program
(termed the Cancer Avatar Project).
This position requires advanced knowledge of rodent (mouse)
surgical procedures, and primary mammalian cell culture. In
addition, knowledge of cancer genomics and pharmacogenomics are
highly desirable. Good working knowledge of cancer biology,
biochemistry, molecular and cell biology are required. Previous
publications in the field of cancer research are highly desirable.
Knowledge of handling of human tissues and blood and prior
experience in animal models of cancer (xenograft) is required. PhD
with less than 2 years postdoctoral experience preferred.
Supervision will be provided jointly by Dr. Kashani-Sabet and other
senior scientists affiliated with the Avatar program. Must be
highly collaborative, team-oriented, but also capable of working
independently. Strong written/verbal communication skills are
required. The position may require occasional weekend and evening
duties. Salary is commensurate with experience.
You can learn more about our research projects here:
- De Semir D, Bezrookove V, Nosrati M, Scanlon KR, Singer E,
Judkins J, Rieken C, Wu C, Shen J, Schmudermayer C, Dar AA, Miller
JR 3rd, Cobbs C, Yount G, Desprez PY, Debs RJ, Salomonis N,
McAllister S, Cleaver JE, Soroceanu L, Kashani-Sabet M. PHIP drives
glioblastoma motility and invasion by regulating the focal adhesion
complex. Proc Natl Acad Sci USA. 2020 Apr 21;117(16):9064-9073.
doi: 10.1073/pnas.1914505117. Epub 2020 Apr 9.
- De Semir D, Bezrookove V, Nosrati M, Dar AA, Wu C, Shen J,
Rieken C, Venkatasubramanian M, Miller JR III, Desprez P-Y,
McAllister S, Soroceanu L, Debs RJ, Salomonis N, Schadendorf D,
Cleaver JE, Kashani-Sabet M. PHIP as a therapeutic target for
driver-negative subtypes of melanoma, breast, and lung cancer. Proc
Natl Acad Sci USA. 2018 Jun 4. pii: 201804779. doi:
10.1073/pnas.1804779115. Epub 2018 Jun 4.
- Dar AA, Nosrati M, Bezrookove V, de Semir D, Majid S, Thummala
S, Sun V, Tong S, Leong SPL, Minor D, Billings PR, Soroceanu L,
Debs R, Miller JR III, Sagebiel RW, Kashani-Sabet, M. The role of
BPTF in melanoma progression and in response to BRAF-targeted
therapy. J Natl Cancer Inst, 2015 Feb 23; 107(5). Pii: djv034.
Doi:10.1093/jnci/djc034. PMID: 25713167; PMC4555639
- Kashani-Sabet M, Nosrati M, Miller JR III, Sagebiel RW, Leong
SPL, Lesniak A, Tong S, Lee SJ, Kirkwood JM. Prospective validation
of molecular prognostic markers in cutaneous melanoma: a
correlative analysis of E1690. Clin Cancer Res, 2017 Nov 15;
23(22):6888-6892. doi: 10.1158/1078-0432.CCR-17-1317. Epub 2017 Aug
Doctoral degree in Epidemiology or Biology required (Doctorate,
- At least 1 year of experience working in clinical,
translational, and/or epidemiologic research is required.
- Experience in designing research studies is desired.
- Areas of interest: Biological aging, the genetics of aging, and
- Strong interest and background in clinical research, public
health or epidemiological research;
- Familiar with computational and data analysis.
- Familiar with developing publications.
- An interest in data pooling and technological infrastructure
used to conduct research studies.
- Can prepare manuscripts for publication.
- Comfortable using Word, Excel, PowerPoint, SAS and Stata.
- Able to prepare grant applications for career development (i.e.
R or K awards).
- Ability to analyze data with the aid of statisticians and
programmers produces tables and figures.
Keywords: Sutter Health, San Francisco , Post Doctoral Scientist, Other , San Francisco, California
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