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Senior Bioinformatics Scientist, Antibody Discovery

Company: LIGAND PHARMACEUTICALS INCORPORATED
Location: Emeryville
Posted on: June 12, 2021

Job Description:

OmniAb, part of the Ligand family of companies is looking for a Senior Bioinformatics Scientist to join its Antibody Discovery group. The candidate will support all data driven efforts of the OmniAb antibody discovery team selecting panels of therapeutic candidate antibodies. A successful candidate has strong bioinformatics skills and a background in applied data science for antibody discovery, molecular biology, and algorithm development. Teaching and training of junior staff and non-informatics trained scientists will be an essential part of this role. Additionally, the role will involve coordinating experiments across a variety of internal and external projects; so, strong communication skills and a collaborative nature is a must. The candidate will report directly to the Director of Antibody Discovery. This position will be in Emeryville, CA.

Essentials for Working at Ligand * The OmniAb group at Ligand consists of dynamic and innovative scientists that employ a variety of novel platforms to support our partners in discovering the best antibodies possible for their therapeutic applications. At the core of OmniAb is the ability to engineer animals to generate affinity matured human sequence antibodies for use in conventional and novel formats. We leverage our proprietary animals with state-of-the-art technology in antigen design, immunization methods and high-throughput single B cell screening to facilitate discovery of best-in-class antibodies. We are looking for accomplished team players who are enthusiastic to contribute to the technological frontier of antibody discovery, and passionate in their desire to collaborate with partners to develop next generation therapeutics. See OmniAb.com for more details about the exciting science being performed at Ligand.

Essential Role Responsibilities

  • Guide data driven antibody discovery efforts
  • Supervise junior bioinformatics staff
  • Drive data standardization and integration
  • Conceptualize, develop and integrate algorithms and scripts to process data from various sources
  • Help to develop OmniAb informatics team and platform
  • Guide therapeutic antibody discovery efforts for partner and/or internal projects
  • Preparation and communication of experimental data reports for partner and internal antibody discovery programs

Non-essential Role Responsibilities Include

  • Presentations at major antibody conferences
  • Other duties as required
  • PhD in Bioinformatics, Computational Biology/Immunology, Statistics or Mathematics with 2+ yrs relevant experience - or
  • BS or MS in Biology or equivalent, with extensive industry experience (5+ years) including antibody discovery
  • Documented coding skills in python and/or R in the context of large-scale biological data (i.e. high throughput assay data such as NGS) is required
  • Experience in algorithm development is preferred
  • Experience in project management is preferred
  • Experience in antibody discovery and/or (computational) immunology is preferred
  • Experience with data from antibody characterization techniques such as ELISA, FACS and cellular assays is preferred
  • Hands-on experience in molecular biology, cell biology, protein biology is considered a strong asset
  • Hands-on experience in antibody cloning and expression is considered a strong asset
  • Eagerness to learn new methods and apply knowledge to a steady stream of new projects with distinct goals
  • Must demonstrate well-developed communication, record keeping, organizational skills, and the ability to work in a team environment

Benefits

  • The company offers competitive benefits including medical, dental, vision, Short/Long term disability and life insurance, as well as 401(k) match, Stock Options, Bonus, and paid time leave.

Additional Information

  • All new hires are required to go through a background and reference check
  • Ligand is an EEO/AA/Disability/Vets employer
  • Must be legally authorized to work in the US without sponsorship
  • Ligand celebrates the diversity of life and welcomes all individuals to apply

Keywords: LIGAND PHARMACEUTICALS INCORPORATED, San Francisco , Senior Bioinformatics Scientist, Antibody Discovery, Other , Emeryville, California

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