Associate Principal Scientist, Mass Spectrometry
Company: Cleveland Clinic Lerner College Of Medicine
Location: San Francisco
Posted on: April 9, 2021
American Nursing Informatics Association (ANIA)
- Associate Principal Scientist, Mass Spectrometry M Associate
Principal Scientist, Mass Spectrometry Merck & Co., Inc.
The Pharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM)
function of South San Francisco is seeking a dynamic and
collaborative scientist for the Absorption, Distribution,
Metabolism, and Excretion (ADME) group. The Associate Principal
Scientist will be a member of the function providing expertise as a
key component of the multi-disciplinary drug discovery effort in
South San Francisco, with a focus on supporting preclinical
development of therapeutics of various modalities through an
integrated understanding of drug disposition and pharmacology.
Therapeutic areas may include immunology and oncology,
cardiovascular and metabolic disease, and ophthalmology.
The Associate Principal Scientist will work within teams of highly
collaborative scientists to contribute to the characterization of
next-generation biologics. The Associate Principal Scientist will
design and conduct mass spectrometry experiments to: 1). assess
molecular liabilities to inform molecular engineering and
bioanalytical strategy; 2). provide a mechanistic understanding of
protein therapeutics immunogenicity through proteomic analysis to
guide molecular engineering. The Associate Principal Scientist will
have the opportunity to represent PPDM in novel biologics discovery
teams, in which case, she/he will be responsible for the design,
implementation, and analysis of in silico, in vitro and in vivo
studies to understand the impact of disease biology and
pharmacologic response on drug disposition.
The candidate should be an experienced industrial scientist with
hands-on expertise with protein and peptide Mass Spectrometry-based
analytics and characterization. The candidate should have
experience with informatic tools in support of protein MS
applications. The ideal candidate should have experience
characterizing potential liabilities through in silico, in vitro ,
and in vivo characterizations beyond biotransformation that may
impact the overall pharmacokinetic and pharmacodynamic profile,
including immunogenicity, aggregation, target interactions, etc.
The ideal candidate will have track record of team-facing
experience. The Associate Principal Scientist must be able to work
collaboratively in a fast-paced environment and have excellent
scientific, interpersonal, and communication skills.
Education Minimum Requirement:
- MSc or PhD. in Analytical Chemistry, Pharmaceutical Sciences,
Pharmacology, Biochemistry, Immunology, Biological Sciences, or
Required Experience and Skills
- MSc with 8+ years, or PhD with 4+ years of combined industry
and/or postdoctoral experience in relevant field with focus on Mass
Spectrometry science and supported discovery and/or regulated
- Demonstrated experience in conducting mass spectrometry and/or
proteomics experiments including sample preparation, mass
spectrometer operation and data analysis and informatics
- Demonstrated experience in supporting novel biologics
modalities and platforms, e.g. ADC, multi-specific antibody
therapeutics, recombinant fusion proteins, oligonucleotide
therapeutics, peptide therapeutics, etc.
- Good understanding of biologics drug discovery and development
- Familiarity with electronic laboratory notebook applications
and good documentation practices
Preferred Experience and Skills:
- Experience with mass spectrometry-based characterization of
- Experience with discovery and clinical immunogenicity of
- Experience leading ADME/PK support of discovery or development
programs in the biologics space.
- Experienced in integrating preclinical ADME, PK, and
pharmacology for establishing exposure-response relationships and
enabling PK/PD modeling efforts to guide engineering and set
anticipated therapeutic profile boundaries.
- Contribution (strategy and results) to preclinical data package
to enable implementation of appropriate translational strategies
for lead candidate selection and FIH dose projections.
We are a research-driven biopharmaceutical company. Our mission is
built on the simple premise that if we "follow the science" that
great medicines can make a significant impact to our world. We
believe that a research-driven enterprise dedicated to world-class
science can succeed by inventing medicine and vaccine innovations
that make a difference for patients across the globe.
Who we are ...
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in
the United States and Canada and MSD everywhere else. For more than
a century, we have been inventing for life, bringing forward
medicines and vaccines for many of the world's most challenging
diseases. Today, our company continues to be at the forefront of
research to deliver innovative health solutions and advance the
prevention and treatment of diseases that threaten people and
animals around the world.
What we look for ...
In a world of rapid innovation, we seek brave Inventors who want to
make an Impact in all aspects of our business, enabling
breakthroughs that will affect generations to come. We encourage
you to bring your disruptive thinking, collaborative spirit and
diverse perspective to our organization. Together we will continue
Inventing For Life, Impacting Lives while Inspiring Your Career
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee
Placement, all employees subject to this policy are required to
have a minimum of twelve (12) months of service in current position
prior to applying for open positions.
If you have been offered a separation benefits package, but have
not yet reached your separation date and are offered a position
within the salary and geographical parameters as set forth in the
Summary Plan Description (SPD) of your separation package, then you
are no longer eligible for your separation benefits package. To
discuss in more detail, please contact your HRBP or Talent
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engage in a hiring process that exhibits their true capabilities.
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diverse, talented, and committed people together. The fastest way
to breakthrough innovation is when diverse ideas come together in
an inclusive environment. We encourage our colleagues to
respectfully challenge one another's thinking and approach problems
collectively. We are an equal opportunity employer, committed to
fostering an inclusive and diverse workplace.
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp &
Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited
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/ resumes submitted by search firms to any employee at our company
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Flexible Work Arrangements:
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Number of Openings:
- Job ID: 56343476
- Position Title: Associate Principal Scientist, Mass
- Company Name: Merck & Co., Inc.
- Job Function: Other
- Job Type: Full-Time View your connections at Merck & Co., Inc.
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Keywords: Cleveland Clinic Lerner College Of Medicine, San Francisco , Associate Principal Scientist, Mass Spectrometry, Other , San Francisco, California
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