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Associate Principal Scientist, Mass Spectrometry

Company: Cleveland Clinic Lerner College Of Medicine
Location: San Francisco
Posted on: April 9, 2021

Job Description:

American Nursing Informatics Association (ANIA)

  • Associate Principal Scientist, Mass Spectrometry M Associate Principal Scientist, Mass Spectrometry Merck & Co., Inc. DescriptionJob Description

    The Pharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM) function of South San Francisco is seeking a dynamic and collaborative scientist for the Absorption, Distribution, Metabolism, and Excretion (ADME) group. The Associate Principal Scientist will be a member of the function providing expertise as a key component of the multi-disciplinary drug discovery effort in South San Francisco, with a focus on supporting preclinical development of therapeutics of various modalities through an integrated understanding of drug disposition and pharmacology. Therapeutic areas may include immunology and oncology, cardiovascular and metabolic disease, and ophthalmology.

    The Associate Principal Scientist will work within teams of highly collaborative scientists to contribute to the characterization of next-generation biologics. The Associate Principal Scientist will design and conduct mass spectrometry experiments to: 1). assess molecular liabilities to inform molecular engineering and bioanalytical strategy; 2). provide a mechanistic understanding of protein therapeutics immunogenicity through proteomic analysis to guide molecular engineering. The Associate Principal Scientist will have the opportunity to represent PPDM in novel biologics discovery teams, in which case, she/he will be responsible for the design, implementation, and analysis of in silico, in vitro and in vivo studies to understand the impact of disease biology and pharmacologic response on drug disposition.

    The candidate should be an experienced industrial scientist with hands-on expertise with protein and peptide Mass Spectrometry-based analytics and characterization. The candidate should have experience with informatic tools in support of protein MS applications. The ideal candidate should have experience characterizing potential liabilities through in silico, in vitro , and in vivo characterizations beyond biotransformation that may impact the overall pharmacokinetic and pharmacodynamic profile, including immunogenicity, aggregation, target interactions, etc. The ideal candidate will have track record of team-facing experience. The Associate Principal Scientist must be able to work collaboratively in a fast-paced environment and have excellent scientific, interpersonal, and communication skills.

    Education Minimum Requirement:
    • MSc or PhD. in Analytical Chemistry, Pharmaceutical Sciences, Pharmacology, Biochemistry, Immunology, Biological Sciences, or related field.


      Required Experience and Skills
      • MSc with 8+ years, or PhD with 4+ years of combined industry and/or postdoctoral experience in relevant field with focus on Mass Spectrometry science and supported discovery and/or regulated bioanalytical
      • Demonstrated experience in conducting mass spectrometry and/or proteomics experiments including sample preparation, mass spectrometer operation and data analysis and informatics experience
      • Demonstrated experience in supporting novel biologics modalities and platforms, e.g. ADC, multi-specific antibody therapeutics, recombinant fusion proteins, oligonucleotide therapeutics, peptide therapeutics, etc.
      • Good understanding of biologics drug discovery and development processes.
      • Familiarity with electronic laboratory notebook applications and good documentation practices


        Preferred Experience and Skills:
        • Experience with mass spectrometry-based characterization of complex biologics.
        • Experience with discovery and clinical immunogenicity of biologics.
        • Experience leading ADME/PK support of discovery or development programs in the biologics space.
        • Experienced in integrating preclinical ADME, PK, and pharmacology for establishing exposure-response relationships and enabling PK/PD modeling efforts to guide engineering and set anticipated therapeutic profile boundaries.
        • Contribution (strategy and results) to preclinical data package to enable implementation of appropriate translational strategies for lead candidate selection and FIH dose projections.


          We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

          Who we are ...

          We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

          What we look for ...

          In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

          INVENT.

          IMPACT.

          INSPIRE.

          NOTICE FOR INTERNAL APPLICANTS

          In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

          If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

          Current Employees apply HERE

          Current Contingent Workers apply HERE

          US and Puerto Rico Residents Only:

          Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

          For more information about personal rights under Equal Employment Opportunity, visit:

          EEOC Poster

          EEOC GINA Supplement

          OFCCP EEO Supplement

          We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

          Search Firm Representatives Please Read Carefully
          Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

          Employee Status:
          Regular

          Relocation:
          Domestic

          VISA Sponsorship:

          Travel Requirements:
          10%

          Flexible Work Arrangements:

          Shift:

          Valid Driving License:

          Hazardous Material(s):

          Number of Openings:
          1

          Requisition ID:R100193

          Job Information
          • Job ID: 56343476
          • Position Title: Associate Principal Scientist, Mass Spectrometry
          • Company Name: Merck & Co., Inc.
          • Job Function: Other
          • Job Type: Full-Time View your connections at Merck & Co., Inc. LinkedIn Jobs You May Like M Senior Scientist II, Modeling & Informatics -... Merck & Co., Inc. Senior Scientist II, Modeling & Informatics -... Merck Associate Principal Scientist, Mass Spectrometry East Holly Avenue, Box 56 Pitman, NJ 08071

Keywords: Cleveland Clinic Lerner College Of Medicine, San Francisco , Associate Principal Scientist, Mass Spectrometry, Other , San Francisco, California

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