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Scientific Researcher / Senior Scientific Researcher, In Vit

Company: Genentech
Location: San Francisco
Posted on: April 9, 2021

Job Description:

Scientific Researcher / Senior Scientific Researcher, In Vitro ADME We are seeking a Senior Scientific Researcher with hands on experience in LC-MS/MS analysis and proven capability to perform various in vitro ADME assays including plasma and tissue protein binding, CYP inhibition/induction assay and metabolic stability in various biological matrices. The successful candidate will be highly motivated and diligent, be able to work independently and collaboratively, and have excellent organizational and reporting skills. S/he will work closely with our established team in the Small Molecule DMPK Department, performing both routine and mechanistic in vitro studies to support both drug discovery and development. To accomplish this, the successful individual must be highly skilled in LC-MS/MS instrumentation, method development and trouble-shooting. Prior experience in IND in vitro assay study design and reporting is preferred but not required. Requirements: B.S./M.S. in Chemistry/Biological Sciences or a related field. Relevant experience in in vitro ADME assays is highly desirable, although junior candidates with strong and relevant scientific background will be considered. For the senior level position, demonstrated experience in utilizing LC-MS/MS in high throughput bioanalysis is required. Scientific understanding of drug metabolism, CYP450 enzymes and working experience with liver microsomes and primary hepatocytes is strongly preferred. Drug Metabolism and Pharmacokinetics (DMPK):The DMPK group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state of the art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings. #LI- BK2 #dmpk Who We Are Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. The next step is yours. To apply today, click on the "Apply for this job" button. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page .

Keywords: Genentech, San Francisco , Scientific Researcher / Senior Scientific Researcher, In Vit, Other , San Francisco, California

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