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Staff Research Associate III

Company: University of California
Location: San Francisco
Posted on: November 23, 2020

Job Description:

About UCSF

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

Job Summary

The Rutishauser Lab in the Department of Medicine, Division of Experimental Medicine at UCSF based at Zuckerberg San Francisco General Hospital (ZSFGH) seeks a highly motivated Staff Research Associate III (SRA III) to work as a part-time (85%) research technician and part-time (15%) laboratory manager.

The laboratory focuses on understanding the mechanisms that promote the formation of protective immunity to viral pathogens across different stages of human development. The candidate will work on several highly collaborative projects that seek to (1) identify the cell-intrinsic (i.e., transcriptional and epigenetic) and cell-extrinsic (i.e., inflammatory cytokine and tissue environment) regulators of T cell exhaustion in chronic HIV infection, (2) determine whether HIV-specific CD8+ T cell exhaustion can be overcome by immune-based interventions (e.g., therapeutic vaccination), and (3) determine the molecular basis of altered CD8+ T cell effector differentiation in early human life and the consequences for the formation of protective immunity in infants. The successful candidate will ideally show proficiency with various laboratory techniques and computer programs, including experience with and/or interest in developing skills in cellular immunology assays (flow and mass cytometry) and analysis (including basic programming using R). Duties will include standard and repetitive technical laboratory procedures.

Additional Shift Details

Usually Monday - Friday, 9:00 am - 5:30 pm, but flexibility required at times based on sample/equipment availability

Required Qualifications

* BA/BS degree in a related science and two or more years of recent, directly related work experience following degree completion, utilizing the techniques or methods required by the position (flow and/or mass cytometry, RNA sequencing); or an equivalent combination of education and experience

* Experience working under Biosafety Level 2 (or above) conditions

* Experience with good sterile technique

* Proficiency in tissue and cell processing

* Experience staining cells for flow cytometry assays

* Strong computer literacy skills, including Word and Excel

* Ability to follow written procedures accurately and maintain accurate lab notebook, participant records and specimen inventory

* Strong organizational and communication skills

Note: Physical/health screening required.

Department Name

Medicine-ZSFG-Division of Experimental Medicine

Preferred Qualifications

* M.S./M.A. degree in a biological, chemical or physical science

* Experience working in an immunology laboratory

* Ability to work efficiently within a team environment as well as independently

* Experience with isolation of cells from human blood and tissue specimens by enzymatic digestion, density gradients and magnetic enrichment

* Experience thawing viable cryopreserved cells

* Knowledge of fluorochromes used in flow cytometry

* Experience operating flow cytometers particularly BD LSR-II

* Experience with R programming for analysis of data generated from cellular or molecular biology assays

* Laboratory management experience

Position Type

Full Time

Equal Employment Opportunity
The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Further information about the University of California, San Francisco, is available at diversity.ucsf.edu. UCSF seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.

Keywords: University of California, San Francisco , Staff Research Associate III, Other , San Francisco, California

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