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Scientist, Biologics Analytical Development

Company: Nektar Therapeutics
Location: San Francisco
Posted on: March 29, 2020

Job Description:

Position OverviewThe Scientist, Biologics Analytical Development, is part of Nektar's Biologics CMC organization.Scientist, Biologics Analytical Development, part of Nektar Biologics CMC organization is responsible for product characterization, analytical method development/validation of proteins and protein-conjugates for Nektar Biologic products in pre-clinical and clinical development stages. The candidate will collaborate with other groups on analytical issues, develop testing methodologies to support process development of drug substance and drug product. This candidate should have the ability to independently plan, design, and implement protocols to successfully solve issues related to protein characterization. This is a hands-on bench position, focused on sample preparation, mass spectrometry-based data acquisition, instrument maintenance/troubleshooting and data analysis.Responsibilities:The candidate will develop and validate analytical methods to support late stage drug development activities, including assisting process development scientists to characterize and monitor in-process purification. The individual will be responsible for the whole workflow from sample preparation to data analysis.

  • Perform sample preparation including digestion mapping of regular proteins and protein polymer conjugates
  • Analyze intact proteins and digested peptides following SOP and develop new methods using LC-MS/MS
  • Analyze data to share with collaborators
  • Maintain and troubleshoot Thermo Orbitrap mass spectrometers and Waters UPLC
  • Write and review internal reports, in addition to presenting results and experimental information to departmental colleagues Requirements:
    • Requires a PhD in a scientific discipline and a minimum of 2+ years industrial experience, may include post-doctoral experience.Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered
    • Extensive expertise in developing LC-MS/MS based protein characterization methods such as proteomics and peptide mapping. 2 + years of experience on Thermo Orbitrap mass spectrometer is highly desired
    • Hands-on experience on sample preparation for mass spectrometry-based analysis of proteins
    • Experience in maintaining and troubleshooting UPLC and mass spectrometers
    • Experience in HPLC separation methods such as ion exchange, reversed phase, and size exclusion chromatography, and capillary electrophoresis for proteins is a plus
    • Strong communication skills and exemplary attention to detail We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.

Keywords: Nektar Therapeutics, San Francisco , Scientist, Biologics Analytical Development, Other , San Francisco, California

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