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Principal/ Sr Principal Scientist, Translational Oncology

Company: Hoffmann-La Roche Ltd
Location: San Francisco
Posted on: January 25, 2023

Job Description:

The Position

The Department of Translational Oncology in Genentech Research is seeking a highly motivated Principal/ Sr Principal Scientist to take on the exciting opportunity to lead a group of researchers developing novel cancer therapies. The candidate should have a strong basic understanding of the drivers of oncogenic progression and the tumor interplay with the tumor microenvironment and immune system. This role involves leading a team to explore therapeutic responses, helping define mechanisms of action, elucidating potential biomarkers, and identifying potential combinatorial strategies using pre-clinical animal models. As such the ideal candidate should be technically well-versed in the assessment of potential therapeutics in animal models during drug development. The successful candidate will work closely with other disciplines within Genentech to drive research stage programs into early clinical development, providing scientific and technical leadership.

Summary of Key Responsibilities:

* Lead translational research group primarily supporting cancer immunotherapy programs.

* Provide in vivo pharmacology expertise to project teams during the discovery and development phases of biologics and small molecule drug discovery programs.

* Define PK/PD/efficacy relationships in collaboration with colleagues within DMPK and Research Oncology Discovery labs.

* Develop innovative preclinical animal models that enable interrogation of mechanisms of action, diagnostic hypotheses, and mechanisms of resistance.

* Management of up to 5 direct or indirect reports, including Scientific Researchers and Scientific Supervisors. Develop and assess goals of direct reports.

* Responsible for authoring documents to support regulatory filings, patent applications and manuscripts published in peer-reviewed journals.


A PhD or MD/PhD with post-doctoral training or equivalent experience in oncology, cell biology, immunology, or a related field is required. Ideal candidates with have a minimum of 5 years of research experience in oncology, preferably with experience in both direct oncogenic-targeting approaches as well as immune-oncology experience. The ideal candidate will have demonstrated industry experience or academic achievement, as evidenced by publications in high impact journals, presentations at international conferences, patents, and/or direct involvement of advancing molecules into clinical development. Candidates with strong experience in tumor modeling (in vitro and in vivo), assessment of therapeutic responses using a diverse array of pharmacodynamics assays, high content biomarker assessments, and experience in translational immunology are highly encouraged to apply. The successful applicant will have a high level of understanding of the basic oncogenic drivers and the interplay of tumors with innate and adaptive immune mechanisms at play during cancer development. Candidates are expected to have a strong sense of scientific curiosity and desire to work effectively in a highly collaborative setting. Candidates should have exceptional communication skills and evidence of dedication to translating basic research insights into therapeutics.

Relocation benefits are available for this job posting.



Who we are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Unless entitled to a reasonable accommodation under applicable law, employees are required to be fully vaccinated against COVID-19 in accordance with customer requirements, the company's health and safety obligations and/or applicable law or guidelines.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage.

Keywords: Hoffmann-La Roche Ltd, San Francisco , Principal/ Sr Principal Scientist, Translational Oncology, Healthcare , San Francisco, California

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