Lab Manager / Research Associate in Genomics and Heart Disease - Stanford University
Company: Stanford University
Location: Stanford
Posted on: April 25, 2024
|
|
Job Description:
We are seeking a highly motivated and organized individual to
join us as a Lab Manager and Research Associate in Genomics and
Heart Disease. In this role, the candidate will support three
interrelated laboratories (Jesse Engreitz, Casey Gifford, and
Xiaojie Qiu) in the Stanford Children's Heart Center Basic Science
and Engineering Initiative and Department of Genetics, which are
all located together in the Biomedical Innovations Building on
Stanford main campus. Lab overview: Our overall mission is to
leverage advances in genetics and genomics to cure children's heart
diseases. In particular, DNA regulatory elements in the human
genome, which harbor thousands of genetic risk variants for common
and rare heart diseases and could reveal targets for therapeutics
that aim to precisely tune cellular functions - if only we could
map the complex regulatory wiring that connects 2 million
regulatory elements with 21,000 genes in thousands of cell types in
the human body. We have recently developed new approaches that
could enable mapping this regulatory wiring at massive scale (see
Fulco et al. Science 2016, Fulco et al. Nat Genet 2019, Nasser et
al. Nature 2021), and applied these and other approaches to
understand the genetic basis of congenital heart defects (Gifford
et al. Science 2019, Schricker et al. Nature 2019, Ameen et al.
bioRxiv 2022). We have now identified enhancers that contain
disease variants that affect risk for congenital heart defects, and
aim to study the functions of these enhancers in mouse models and
human cardiac organoids. These studies will ultimately help to
uncover biological mechanisms of congenital heart defects, and help
to guide diagnosis and treatment for children with heart disease.
For information and recent work, see
https://www.caseygiffordlab.com, https://www.engreitzlab.org, and
https://med.stanford.edu/base.html. We are looking for a creative
and passionate person at any stage in their career to lead
management of our combined experimental/computational laboratory.
The Gifford, Engreitz, and Qiu Laboratories are located adjacent to
one another and provide a dynamic, interdisciplinary workplace with
unique access to cutting edge technologies and scientific thought,
with the potential for widespread recognition of scientific
contributions. We value a diversity of values, backgrounds, and
approaches to solving problems. The candidate for this position
should have hands-on experience in molecular biology, genomics, and
cellular assay development; excellent organization,
problem-solving, interpersonal, and collaboration skills;
experience building or managing teams; outstanding verbal and
written communication abilities; ability to adapt to and
effectively manage changes in a fast paced and dynamic environment;
and have a passion for science and sense of urgency to find new
medicines to benefit patients. Candidates with or without prior
laboratory management experience are welcome to apply. On-the-job
training will be provided. In addition to submitting your
application via the Stanford web portal, please email your CV and
cover letter directly to Profs. Casey Gifford
(caseygifford@stanford.edu) and Jesse Engreitz
(engreitz@stanford.edu). Duties include: Make fundamental
discoveries about gene regulation and the genetics of
cardiovascular disease Together with PIs, oversee lab management
including protocols, procedures, inventory, and training Develop
and apply functional genomics techniques, including epigenomics,
single-cell, imaging, and CRISPR-based assays in human cells and/or
in vivo models of disease Train, mentor, and/or supervise lab
members in experimental techniques, scientific design, and
laboratory safety protocols Collaborate with a team of
experimentalists and computational biologists Create scientifically
rigorous visualizations, communications, and presentations of
results Contribute to generation of protocols, publications, and
intellectual property Coordinate ordering for all lab members and
maintain a database to manage these orders. Ensure orders are
placed and delivered in a timely manner Assist with budgeting and
financial overviews, including compiling and reporting purchasing
data and streamlining inventory and costs Develop organizational
tools to improve productivity of lab Maintain and update laboratory
protocols Oversee lab safety compliance and communicate with safety
committees and groups, as well as participate in lab inspections.
Coordinate the repair, evaluation, service contracts, calendar
system, and annual certifications of lab equipment. Maintain a
current chemical inventory. Oversee the maintenance of cold storage
units, including liquid nitrogen. * - Other duties may also be
assigned. DESIRED QUALIFICATIONS: B.S. in Biology, Biochemistry,
Biophysics, Genetics, or related life science field. Highly
motivated candidates of all levels are encouraged to apply.
Hands-on experience in molecular biology or genomics Experience
with quantitative data analysis, CRISPR, and/or single-cell methods
a plus Curiosity in research and creativity in problem-solving A
great team member with strong interpersonal and collaboration
skills Previous leadership or lab management experience a plus
Outstanding verbal and written communication abilities Ability to
adapt to and effectively manage changes in a fast paced and dynamic
environment A passion for science and sense of urgency to find new
medicines to benefit patients EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field and two years of
relevant work experience; or Master's degree in a related
scientific field. KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles. General
computer skills and ability to quickly learn and master computer
programs, databases, and scientific applications. Strong analytical
skills and excellent judgment. Ability to maintain detailed records
of experiments and outcomes. Ability to work under deadlines with
general guidance is essential. Excellent organizational skills and
demonstrated ability to accurately complete detailed work.
CERTIFICATIONS & LICENSES: None. PHYSICAL REQUIREMENTS*: Frequently
stand, walk, twist, bend, stoop, squat, grasp lightly, use fine
manipulation, grasp forcefully, perform desk-based computer tasks,
use telephone, write by hand, lift, carry, push and pull objects
weighing over 40 pounds. Occasionally sit, kneel, crawl, reach and
work above shoulders, sort and file paperwork or parts. Rarely
climb, scrub, sweep, mop, chop and mix or operate hand and foot
controls. Must have correctible vision to perform duties of the
job. Ability to bend, squat, kneel, stand, reach above shoulder
level, and move on hard surfaces for up to eight hours. Ability to
lift heavy objects weighing up to 50 pounds. Ability to work in a
dusty, dirty, and odorous environment. Position may require
repetitive motion. *- Consistent with its obligations under the
law, the University will provide reasonable accommodation to any
employee with a disability who requires accommodation to perform
the essential functions of his or her job. WORKING CONDITIONS: May
require working in close proximity to blood borne pathogens. May
require work in an environment where animals are used for teaching
and research. Position may at times require the employee to work
with or be in areas where hazardous materials and/or infectious
diseases are present. Employee must perform tasks that require the
use of personal protective equipment, such as safety glasses and
shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research
requirements and business needs. The expected pay range for this
position is $67,000 to $88,000 per annum. Stanford University
provides pay ranges representing its good faith estimate of what
the university reasonably expects to pay for a position. The pay
offered to a selected candidate will be determined based on factors
such as (but not limited to) the scope and responsibilities of the
position, the qualifications of the selected candidate,
departmental budget availability, internal equity, geographic
location and external market pay for comparable jobs. At Stanford
University, base pay represents only one aspect of the
comprehensive rewards package. The Cardinal at Work website
(https://cardinalatwork.stanford.edu/benefits-rewards) provides
detailed information on Stanford's extensive range of benefits and
rewards offered to employees. Specifics about the rewards package
for this position may be discussed during the hiring process. WORK
STANDARDS (from JDL): Interpersonal Skills: Demonstrates the
ability to work well with Stanford colleagues and clients and with
external organizations. Promote Culture of Safety: Demonstrates
commitment to personal responsibility and value for safety;
communicates safety concerns; uses and promotes safe behaviors
bases on training and lessons learned. Subject to and expected to
comply with all applicable University policies and procedures,
including but not limited to the personnel policies and other
policies found in the University's Administrative Guide,
http://adminguide.stanford.edu.
Keywords: Stanford University, San Francisco , Lab Manager / Research Associate in Genomics and Heart Disease - Stanford University, Executive , Stanford, California
Click
here to apply!
|