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Sr Scientist-Core Director

Company: Blood Systems Group
Location: San Francisco
Posted on: January 27, 2023

Job Description:

Job Description - Sr Scientist-Core Director (222844) Sr Scientist-Core Director - 222844 Organization BSI Business Group Primary Location United States of America-California-San Francisco Work Locations Vitalant 270 Masonic Ave Employee Status Full-time, Regular Shift Day Job Travel No Job Posting Close Date Mar 1, 2023 Job Function Research and Development The director of the Molecular Transfusion Core (MTC) is an outstanding and detail-oriented molecular biologist, with experience in real-time PCR assay development/optimization and next-generation sequencing, who leads and manages the work of this mission-essential core laboratory at Vitalant Research Institute (VRI). The MTC laboratory specializes in design and performance of molecular assays for nucleic acid detection and quantification to assist VRI scientists and collaborators in a variety of research studies. The director supervises and mentors a team of 3 to 5 research staff, is responsible for oversight of daily operations, and is the leader of innovation within the core. The MTC director works with VRI investigators, other core lab leaders, and research administration to prepare research proposals, develop collaborations, lead authorship on abstracts and journal manuscripts, and present research findings. The director reports to the Vice President for Research and Scientific Programs at Vitalant. More about the MTC: To facilitate the use and tailoring of molecular methodologies by VRI scientists and collaborators, the MTC centralizes the process of DNA and RNA extraction and quantification, primer and probe design, nucleic acid amplification, nucleic acid sequencing, and data analysis, particularly for large multicenter research studies. Molecular assays for the specific detection, quantification and sequencing of nucleic acids are critical tools for infectious disease screening, discrimination of genetic variants, characterization of infection reservoirs, and immune cell profiling. Real-time PCR assays specific for transfusion-transmitted viruses and parasites are used in studies that aim to define prevalence and duration of infection in blood donors and transfusion recipients. Allele-specific PCR assays allow for the detection of donor genetic material within recipient cells as a result of infusion or transplantation, and sequencing of viral and parasite DNA/RNA is employed in molecular surveillance of infected donors. The MTC currently has one Hologic transcription mediated amplification (TMA) Panther--- platform, and one Grifols TMA Panther--- platform. In current projects, both instruments are used for detection and/or quantification of HIV, HCV, HBV, WNV, DENV, ZIKV, babesia, malaria and other agents of concern for blood safety. Developing and expanding VRI's capacity in single cell sequencing is a current priority, and the MTC director will have access to the 10X Genomics Chromium iX, Bio-Rad ddSEQ, and Mission Bio Tapestri instruments at VRI to implement single-cell RNA-seq, ATAC-seq, DNA-seq and multi-omics protocols. Core Duties and Responsibilities: Independently manage and oversee operations of the MTC while integrating with the other Vitalant Research Institute Cores. Develop quotes for core services offered by the MTC in collaboration with Vitalant Research Institute administrative staff. Make decisions regarding lab equipment maintenance, service plans, upgrades and purchases. Plan, monitor and evaluate timelines for multiple simultaneous projects and studies, and manage prioritization of schedules and resources. Prepare technical progress reports and evaluate budget status for grants and contracts. Contribute to writing and budget preparation for grant proposals, including generating preliminary data. Interface with investigators to understand project needs and customize core services. Supervise and support research staff, including assisting with troubleshooting, directing work on projects, performance management, and hiring. Research Duties and Responsibilites: Design experimental approaches for research projects utilizing nucleic acid amplification testing and sequencing; develop and validate new protocols. Provide technical expertise in nucleic acid extraction and quality control, quantitative real-time PCR, nucleic acid target-capture, transcription-mediated amplification, and next-generation sequencing. Analyze and interpret data; prepare, document and present detailed methods; generate figures and describe results. Lead the development and writing of manuscripts and present ongoing work at meetings and conferences. Ongoing review of literature to maintain current knowledge related to specific studies and techniques. Actively participate in meetings with collaborators to discuss research progress and data interpretation; identify new research directions and synergies Education and Experience: Ph.D. and postdoctoral training in molecular biology, cell biology, virology, microbiology or a related scientific field. Lab management and supervisory experience are preferred. Demonstrated experience with molecular assay design and performance. Experience with large, multicenter research studies preferred. Skills/Abilities Well-developed research skills and knowledge in specific field, clinical and/or research procedures and techniques. Ability to prioritize and execute multiple tasks and meet deadlines. - Must possess exceptional oral and written communication, and interpersonal skills. - Strong detail orientation, analytical ability and organization skills. - Able to understand, follow, and give precise written and verbal directions and procedures, and perform all activities safely and accurately. Solid computer skills to include statistical analysis. Ability to interpret and explain the theoretical basis of work performed. Ability to apply understanding of scientific theory to the structure and execution of research experiments. Able to perform work duties with tact, diplomacy, and confidentiality when working with research study participants. - Able and willing to work with hazardous material, which may include biohazards, radioisotopes, and chemicals, in compliance with health and safety guidelines and regulations. - Function independently and as a harmonious member of a team. Salary range from $125,000-$145,000.00 per annum ******************************************************************************************* - EEO/Minorities/Females/Disabled/Veterans Our organization is an equal employment/affirmative action employer. If you need accommodation for any part of the employment process because of a medical condition or disability, please send an e-mail to -accommodation@bloodsystems.org -or call 1-844-220-2612 to let us know the nature of your request. A representative will respond to accommodation requests within two business days. Please note that this email/phone number is for medical/disability accommodations only and any other inquiries will not receive a response. For more EEO information about applicant rights -click here For information about Pay Transparency rights -click here Our organization participates in E-Verify, for more information -click here -All candidates who receive a conditional written offer of employment will be required to undergo a pre-employment drug test in accordance with the Company's established guidelines. Vitalant is an equalopportunity employer.EEO/Minorities/Females/Disabled/VeteransOur organization isan equal employment/affirmative action employer. If you needaccommodation for any part of the employment process because of amedical condition or disability, please send an email toto let us know the nature of your request.careers@vitalant.org Please see thebelow information about applicant rights and our commitment tocompliance:All candidates whoreceive a conditional written offer of employment will be requiredto undergo a pre-employment drug test in accordance with theCompany's established guidelines.

Keywords: Blood Systems Group, San Francisco , Sr Scientist-Core Director, Executive , San Francisco, California

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