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Sr Scientist / Engineer, Polysaccharide Process Development

Company: SutroVax Inc.
Location: San Francisco
Posted on: September 15, 2019

Job Description:

Company Profile:SutroVax is a biopharmaceutical company dedicated to the delivery of best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent serious infectious diseases. SutroVax's lead product candidate is a pneumococcal conjugate vaccine (PCV) that is designed to prevent invasive pneumococcal disease (IPD) caused by Streptococcus pneumoniae. SutroVax's broad-spectrum PCV is designed to provide expanded protection against circulating strains of pneumococcus and has the potential to replace the current vaccines used in infants and adults. The current mainstay vaccine only covers approximately 40% of the circulating strains causing IPD yet generates $6B in annual sales. SutroVax has generated positive pre-clinical proof-of-concept with its significantly broader-spectrum PCV compared head-to-head to current vaccines using well accepted immunological endpoints. In addition to its lead PCV product candidate, the Company also has a promising early-stage pipeline addressing other important disease areas.--SutroVax's conjugate vaccines are developed utilizing the Company's exclusive rights to Sutro Biopharma's Xpress CF Platform, a cell-free protein synthesis technology. SutroVax closed its $85M Series C round in May of 2018 and is financed by a world-class syndicate of private equity, venture capital and corporate venture investors with over $170M in capital raised since 2015.--Summary:---SutroVax is looking for an energetic and talented Sr Engineer/Scientist to contribute to the Polysaccharide development and manufacturing function within the CMC team. SutroVax is developing a multi-valent polysaccharide-based conjugate vaccine, based on a novel carrier protein produced using the Xpress CF platform. Polysaccharides are a critical component in conjugate vaccines. The successful candidate will have practical laboratory experience developing processes related to biotechnology, biopharmaceuticals or vaccine industries. The candidate will be eager to utilize and learn new laboratory skills as this person will be responsible for collaboration on experimental design and execution of experiments to further the polysaccharide development and manufacturing program. This position will require 50-80% time in the lab and this person will be able to detail experimental procedures/results in written and presentation formats. The successful candidate will interface closely with the CMC team, write detailed technical reports, present experimental results internally, and interface with external CMO partners. Requirements:M.S. with 2+ years of industry experience; or B.S. with 5+ years of industry experience - Degrees in Bioprocess engineering, Chemical Engineering, Bioengineering or Biotechnology preferredPractical experience with and theoretical knowledge of traditional processing unit operations including Chromatography, TFF, Filtration and Fermentation - Hands-on experience with automated process equipment such as Akta chromatography systems, TFF, DASbox/Gip, Tecan and Ambr systems highly preferredSolid understanding of the principals of DoE (Design of Experiments); practical experience with DoE software; proficient in the design and interpretation of statistically modelled experiments - Ability to organize and execute complex experiments Understanding of engineering principles involved in scaling processes from development lab to pilot / manufacturing plantWorking knowledge of the requirements of GMP manufacturing; hands-on GMP experience a plusAbility to travel to CMO (some international travel required) to perform person-in-plant oversight activitiesDemonstrated success working in a cross-functional team environment on multiple projects; ability to work effectively as a member of a team to deliver resultsStrong interpersonal skills, with excellent written and verbal communication skills Reports to:--Associate Director, Polysaccharide Development and MFG Location: Foster City, California-- Compensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.

Keywords: SutroVax Inc., San Francisco , Sr Scientist / Engineer, Polysaccharide Process Development, Engineering , San Francisco, California

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