Senior Research Associate, Protein Engineering

Company: CytomX Therapeutics, Inc.
Location: San Francisco
Posted on: March 19, 2023

Job Description:

Headquarters Location: South San Francisco, CACandidate Location: HybridTravel Required: 5%Reports To: Pankaj Kumar, Sr. Scientist II, Protein EngineeringPosition Type: ExemptAbout CytomX TherapeuticsCytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel Probody - therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX has a broad pipeline, which comprises seven therapeutic candidates across multiple treatment modalities including antibody-drug conjugates ("ADCs"), T-cell engaging bispecific antibodies ("TCBs"), and immune modulators such as cytokines and checkpoint inhibitors ("CPIs"). Learn more at. Position SummaryWe seek a highly motivated Senior Research Associate to support the protein engineering group. The successful candidate will contribute to the development and engineering of activatable protein therapeutics spanning different modalities including cytokines, antibodies, and bispecific molecules. The candidate will work on DNA construct design, cloning, structure-guided protein, and peptide design, display library screening and protein binding studies.Professional Responsibilities

• Work with project teams (internal and partnered) to design, clone, and optimize activatable protein-therapeutics.
• Engineer novel functionalities into protein scaffolds, leveraging rational design of proteins and peptides and structural modeling.
• Screen display libraries to identify masking peptides for antibodies and cytokines.
• Collaborate closely with the interdisciplinary team to ensure timely progress in research projects and drive technological innovations.
• Prepare, analyze, and present data internally and externally.Minimum Qualifications
  • MS in Biochemistry with 4+ years of experience in the biotechnology or biopharma industry OR BS in Biochemistry with 6+ years of experience in the biotechnology or biopharma industry
  • Hands-on experience with routine molecular biology and cloning techniques (DNA construct designing, PCR, and ligation/recombinase-based cloning, sequence analysis and alignment).
  • Must have experience with ELISAs.Preferred Qualifications
    • Experience with display library screening and next-generation sequencing (NGS).
    • Experience with high-throughput (HTP) protein expression and purification from mammalian cells.
    • Hands-on experience with cytokines and antibodies and their application in cancer.
    • Hands-on with structural biology software like PyMol, Discovery Studio and Schrodinger.
    • Computer programming skills (e.g. Python, R, etc.).
    • Demonstrate a commitment to CytomX values of Integrity, Commitment, Creativity, Teamwork, Accountability, and FunSalary and Benefits
      • The expected salary range for this role based on the primary location for this position in California is $105,000 - $135,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
      • A comprehensive list of that may impact total compensation can be found on our .Conditions of Employment
        • Effective October 2021, employees will be required to attest to and verify whether or not they have been vaccinated for COVID-19 (there is currently no requirement for any employee to obtain booster shots, although the company reserves the right to require boosters at any time, as consistent with applicable law and federal/state agency guidance).
        • If an employee has not been vaccinated against COVID-19 based on sincerely held religious beliefs or medical conditions, they may be required to submit to serial COVID-19 testing in the future. Upon hire, new employees will have three (3) business days to provide attestation to their status with proof of vaccination. Vaccinated employees must provide proof of vaccination.
        • Note: "Vaccinated" means two (2) weeks after a second dose in a two-dose series of the COVID-19 vaccine, such as the Pfizer or Moderna vaccine, or two (2) weeks after the single-dose vaccine, such as Johnson & Johnson's Janssen vaccine.
        • Background investigations are required for all positions at CytomX, consistent with applicable law. CytomX's Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB)CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law.Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre-employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at Notice to Recruiters/Staffing AgenciesRecruiters and staffing agencies should not contact CytomX Therapeutics through this page. We require that all Recruitment Vendors (e.g., search firms, recruitment agencies and staffing companies) have a fully executed, formal written agreement on file with CytomX prior to submitting candidates. Any resumes submitted through the website or directly by Recruitment Vendors will be considered unsolicited. Unsolicited vendor submissions do not constitute any actual or implied contract with CytomX, and CytomX will not be responsible for any purported fees. For more information, please contact our HR team at Please review our to understand what types of personal information we collect from job applicants and why we process such information.

Keywords: CytomX Therapeutics, Inc., San Francisco , Senior Research Associate, Protein Engineering, Engineering , San Francisco, California