Senior Process Engineer, Natural Product Bioactives

Company: Brightseed
Location: San Francisco
Posted on: November 26, 2022

Job Description:

Senior Process Engineer, Natural Product Bioactives Brightseed is a pioneer in biosciences and artificial intelligence that illuminates nature to restore human health. Through Forager - A.I. and clinical evaluation, Brightseed helps companies gain the deepest insight into bioactives and their innovation potential. Forager A.I. accelerates bioactive discovery and biological validation from years to months - and is rapidly revealing new connections between nature and humanity. Brightseed partners with companies across the consumer health continuum to provide novel insights and science-backed health solutions. ABOUT BIOACTIVES Bioactives are small molecule compounds produced by plants, fungi, and microbes that grow in and adapt to environments that present a wide range of challenges to their survival. Bioactives also benefit the health of humans - they are the enlivening caffeine in tea, the powerful antioxidant lycopene in tomatoes, and they inform active ingredients in medicines like Taxol, Aspirin and Metformin, a first-line treatment for Type 2 diabetes, derived from the French lilac flower. Science has long known that bioactives are critical to human health, yet the vast majority remain unknown and uncharted. Brightseed's A.I., Forager -, discovers bioactives in nature and maps them to human health outcomes at a rate and accuracy that was previously impossible. - ABOUT YOU You are an accomplished process engineer, with industry experience working with pilot process equipment and or commercial manufacturing experience. At Brightseed, you will join a team of process engineers that are responsible for exploring and defining methods to extract and purify small molecules from natural feedstocks for use in the food and supplement industry. You will be involved in fundamental process R&D activities at the bench and in pilot facilities as extrusion process development for extraction/melt flow/form and tablets/caplets development, in addition to food prototype development using food processes as homogenization, sterilization unit operations. Ultimately, your work will result in commercial-scale processes for the robust and economic production of our bioactive portfolio. Experience in material science measurements to optimize process and product attributes is a requirement. YOUR IMPACT

• Develop small molecule process isolation schemes and flowsheets that can form the basis for process design and analysis of economics
• Construct spreadsheet models of major process streams and economics based on bench and pilot-scale results
• Evaluate raw material sourcing alternatives in terms of amenability to process unit operations and recoverable yields
• Design and conduct process feasibility trials
• Optimize process performance to reliably achieve product specifications, reduce processing costs and increase productivity
• Identify and engage with pilot and contract manufacturing partners with capabilities amenable to our processes -
• Produce bioactive-rich product formulations at lab-, pilot- and commercial-scales to support product development and regulatory authorization initiativesYOUR QUALIFICATIONS
  • MS in Chemistry, Chemical Engineering, or allied discipline
  • 5+ years of bioseparations and process development experience with an established record of success; or BS with 7+ years experience
  • Hands-on bench experience to support both scale-up and scale-down research efforts
  • Experience building, commissioning and maintaining bench and pilot-scale equipment
  • Ability to adapt and excel in a rapidly moving environment while prioritizing and managing multiple projects/workload
  • Self-starter with good organizational skills; able to work effectively in cross-functional teams, providing strong analytical, process design, and root cause analysis skills
  • Attention to details that includes rigorous review of the data and record-keeping
  • You are a champion for rigorous science, and proactively educate and learn from others
  • Prior experience managing programs and driving them to completionAdditional experience with one or more of the following a plus:
    • Commercial product manufacturing
    • Food processing
    • Plant raw material sourcing and food supply chains - THE BENEFITS YOU'LL ENJOY As a lab based company, where in person collaboration is key to drive innovation, we encourage all team members to be in our office most days each week. However we appreciate and honor the need and desire for flexibility and have implemented a hybrid working model. We have a fully stocked healthy kitchen, a gym onsite, plenty of free parking, weekly team events and a state-of-the-art lab and office. - We offer a competitive total rewards package with team-first benefits programs for full-time employees, including medical, dental and vision coverage, unlimited paid time off, life insurance, disability coverage, employee assistance programs, 401(k) plan, a mental health platform, employee discounts, payroll credits for cell phone and commuter costs and a paid parental leave program. JOIN US, AND BE YOU We are committed to making transformative discoveries with a team-first mentality. Successful team members are truth-seeking and trusting, with the tenacity required to trail blaze in uncharted territory. We are a collaborative team that actively seeks input and values differing perspectives. And we produce tangible results, holding ourselves accountable in the process. - We are also committed to cultivating and preserving a culture of connectedness and inclusion. We grow and learn together, respecting professional and personal experiences, areas of expertise, and types of self expression. - In recruiting for our team, we welcome the unique contributions that each one of us brings in terms of education, opinions, culture, color, ethnicity, race, sex, gender identity and expression, nation of origin, age, languages spoken, veteran's status, religion, different abilities, sexual orientation and beliefs.

Keywords: Brightseed, San Francisco , Senior Process Engineer, Natural Product Bioactives, Engineering , San Francisco, California